Y16, also known as RhoA-IN-Y16, is a RhoA inhibitor, Y16 blocks the binding of LARG, a DBL-family Rho guanine nucleotide exchange factor, with Rho (Kd = 80 nM). Y16 specifically inhibits LARG catalyzed activation of RhoA and RhoA signaling pathways. Y16 blocks the growth and migration of MCF7 breast cancer cells.

Product information

CAS Number: 429653-73-6

Molecular Weight: 384.43

Formula: C24H20N2O3

Chemical Name: (4E)-4-({3-[(3-methylphenyl)methoxy]phenyl}methylidene)-1-phenylpyrazolidine-3,5-dione

Smiles: CC1=CC(COC2=CC(/C=C3\C(=O)NN(C4C=CC=CC=4)C\3=O)=CC=C2)=CC=C1

InChiKey: ITMLWGWTDWJSRZ-PXLXIMEGSA-N

InChi: InChI=1S/C24H20N2O3/c1-17-7-5-9-19(13-17)16-29-21-12-6-8-18(14-21)15-22-23(27)25-26(24(22)28)20-10-3-2-4-11-20/h2-15H,16H2,1H3,(H,25,27)/b22-15+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.