Recombinant Human IL10RB/IL10R2 Protein (Fc Tag)

Size: 50μg

Catalogue Numbers: PKSH032564-50

Citations, Manuals and MSDS Available upon request.

Abbreviation: IL10RB; IL10R2

Target Synonym: CDW210B; CRF2-4; CRFB4; D21S58; D21S66; IL-10R2; Interleukin-10 receptor subunit beta(IL10RB); Cytokine receptor class-II member 4; Cytokine receptor family 2 member 4; Interleukin-10 receptor subunit 2

UNIProt ID: Q08334

Research Areas: Signal Transduction; immunology;

Target Species: Human

Expression Host: HEK293 Cells

Fusion Tag: C-Fc

Accession: Q08334

Background: Interleukin-10 receptor subunit beta(IL10RB), also known as Cytokine receptor class-II member 4, Cytokine receptor family 2 member 4, Interleukin-10 receptor subunit 2, belongs to the type II cytokine receptor family. IL10RB is a single- pass type I membrane protein and contains two fibronectin type-III domains. It is an accessory chain which is essential for the active interleukin 10 receptor complex. Coexpression of IL10RB and IL10RA proteins has been shown to be required for IL10-induced signal transduction. Defects in IL10RB are the cause of inflammatory bowel disease type 25 (IBD25) which is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology.

Sequence: Met20-Ser220

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 .
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 50.6 kDa

Observed MW: 65-90 kDa

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Research Use Only