Fumitremorgin B is a tremorgenic mycotoxin. Fumitremorgin B exhibits significant antifungal activities, with MICs of 6.25-50 μg/mL.

Product information

CAS Number: 12626-17-4

Molecular Weight: 479.57

Formula: C27H33N3O5

Chemical Name: (1R,2S,12S,15S)-1,2-dihydroxy-7-methoxy-10-(3-methylbut-2-en-1-yl)-12-(2-methylprop-1-en-1-yl)-10,13,19-triazapentacyclo[11.7.0.0³,¹¹.0⁴,⁹.0¹⁵,¹⁹]icosa-3(11),4,6,8-tetraene-14,20-dione

Smiles: CC(C)=C[C@H]1C2=C([C@H](O)[C@@]3(O)C(=O)N4CCC[C@H]4C(=O)N31)C1=CC=C(C=C1N2CC=C(C)C)OC

InChiKey: WEIYXEFMCIRZHC-MWGWWEMPSA-N

InChi: InChI=1S/C27H33N3O5/c1-15(2)10-12-28-20-14-17(35-5)8-9-18(20)22-23(28)21(13-16(3)4)30-25(32)19-7-6-11-29(19)26(33)27(30,34)24(22)31/h8-10,13-14,19,21,24,31,34H,6-7,11-12H2,1-5H3/t19-,21-,24-,27+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Fumitremorgin B (3 or 4 days) inhibits the proliferation of U937 and PC3 cells, with IC50 of 14.12 and 43.36 μM, respectively. Fumitremorgin B exhibits antifungal activities against the phytopathogenic fungi B. cinerea, A. solani, A. alternata, C. gloeosporioides, F. solani, F. oxysporum f. sp. niveum, F. oxysporum f. sp. vasinfectum, and G. saubinettii, with MICs of 6.25-50 μg/mL.

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