Advil Cold and Sinus 20 Coated CapletWhat is Advil? Advil (ibuprofen) is a nonsteroidal anti inflammatory drug (NSAID). Ibuprofen works by reducing hormones that cause inflammation and pain in the body. Advil is used to reduce fever and treat pain or inflammation caused by many conditions such as headache, toothache, back pain, arthritis, menstrual cramps, or minor injury. Advil is used in adults and children who are at least 2 years old. For children under 2 years check with a doctor.