is a two-mechanism, next-generation metabolic and blood glucose support formula combining Dihydroberberine (DHB), the naturally occurring bioactive metabolite of berberine with five times greater bioavailability than standard berberine HCl, with InSea2, a patented brown seaweed polyphenol blend from sustainably harvested Ascophyllum nodosum and Fucus vesiculosus, plus Chromium as chromium nicotinate glycinate chelate, in a single pre-meal capsule designed to support a healthy glycemic response to food, healthy blood glucose levels, healthy insulin sensitivity, and the prevention of post-meal blood glucose spikes.

The "Duo" in Berberine ES-5 Duo refers to the two-mechanism approach that distinguishes this formula from standard berberine. Most berberine supplements deliver berberine HCl and rely on intestinal conversion to dihydroberberine (DHB) before the compound becomes maximally bioavailable. Berberine ES-5 Duo delivers DHB directly, bypassing this conversion step and achieving five times greater bioavailability at a lower milligram dose than standard berberine HCl. DHB activates AMPK (AMP-activated protein kinase) through the same mechanism as berberine HCl, supporting glucose uptake, fatty acid oxidation, and insulin sensitivity, but with superior pharmacokinetics.

InSea2 addresses the post-meal glycemic response through a completely distinct and complementary mechanism. InSea2 is a patented blend of phlorotannin polyphenols derived from two brown seaweed species, Ascophyllum nodosum and Fucus vesiculosus, standardized to 20% polyphenols. These phlorotannins inhibit alpha-amylase and alpha-glucosidase, the two primary carbohydrate-digesting enzymes in the intestine, slowing the breakdown and absorption of dietary carbohydrates and blunting the post-meal blood glucose rise that follows carbohydrate-containing meals. Where DHB supports cellular glucose utilization and metabolic insulin sensitivity, InSea2 supports the upstream reduction of how quickly glucose enters the bloodstream from digested food. Together they cover both the rate of glucose entry and the cellular response to glucose, providing synergistic and complementary coverage of the glycemic response.

Chromium nicotinate glycinate chelate provides the third layer of metabolic support, enhancing insulin receptor sensitivity and glucose transporter expression to support the body's own insulin signaling efficiency.

Best taken before meals to position InSea2's carbohydrate enzyme inhibition activity at the moment of maximum dietary carbohydrate exposure. Formulated to exclude wheat, gluten, yeast, soy protein, dairy, fish, shellfish, peanuts, tree nuts, egg, GMO-derived ingredients, artificial colors, sweeteners, and preservatives. NSF GMP-certified XYMOGEN professional formula. 60 vegetarian capsules, 60 servings.

Key Benefits:

• Five times greater bioavailability than standard berberine HCl through direct DHB delivery
• Supports healthy blood glucose levels through AMPK activation and improved insulin sensitivity
• InSea2 supports healthy glycemic response to meals by slowing carbohydrate digestion and absorption
• Dual-mechanism coverage: cellular glucose utilization (DHB) and post-meal glucose entry (InSea2)
• Chromium nicotinate glycinate chelate supports insulin receptor sensitivity
• Supports healthy lipid metabolism and cardiovascular metabolic health
• Supports healthy body composition alongside diet and lifestyle changes
• Particularly effective for clients managing post-meal blood sugar spikes and carbohydrate sensitivity
• Pre-meal dosing format maximizes InSea2 carbohydrate enzyme inhibition at the right time
• No conversion step required: DHB is already in its bioactive form
• Formulated to exclude gluten, dairy, soy, GMOs, and artificial ingredients
• NSF GMP-certified XYMOGEN professional formula

What's Inside — Full Supplement Facts (per 1-capsule serving):

Chromium (as Chromium Nicotinate Glycinate Chelate) — 7.5 mcg (21% DV) — An Albion-sourced chelated chromium providing the trace mineral that enhances insulin receptor binding, promotes GLUT4 glucose transporter expression on cell membranes, and supports healthy insulin signaling efficiency. Chromium nicotinate glycinate chelate is the most bioavailable chelated chromium form available, providing superior absorption over chromium picolinate or chromium chloride.

InSea2 Brown Seaweed Blend (Ascophyllum nodosum and Fucus vesiculosus, 20% polyphenols) — 250 mg — InSea2 is a registered trademark of innoVactiv Inc., a patented blend of phlorotannin polyphenols derived from two species of sustainably harvested, wildcrafted brown seaweed. Phlorotannins from these seaweed species competitively and reversibly inhibit alpha-amylase (the pancreatic enzyme that breaks down starch into disaccharides) and alpha-glucosidase (the brush border enzyme that breaks down disaccharides into monosaccharides for absorption), slowing the rate of carbohydrate digestion and reducing the peak post-meal blood glucose concentration. Taken before meals, InSea2 positions its enzyme inhibition activity at the moment of maximum dietary carbohydrate exposure, blunting the glycemic response without completely blocking carbohydrate absorption. Multiple human clinical trials on InSea2 demonstrate a meaningful reduction in postprandial blood glucose and insulin response in healthy individuals and those with carbohydrate sensitivity.

Dihydroberberine (DHB) — The naturally occurring reduced metabolite of berberine that is the primary bioactive form absorbed and utilized at the cellular level. When standard berberine HCl is consumed, intestinal bacteria partially convert it to DHB before absorption, and this conversion is incomplete and variable. By delivering DHB directly, Berberine ES-5 Duo bypasses this conversion bottleneck, achieving five times greater bioavailability at a lower milligram dose. DHB activates AMPK (AMP-activated protein kinase), promoting cellular glucose uptake via GLUT4 transporter expression, fatty acid oxidation, and inhibition of hepatic gluconeogenesis — the same mechanisms responsible for berberine's metabolic benefits, now with superior pharmacokinetics.

Other Ingredients: Capsule (hypromellose and water), microcrystalline cellulose, ascorbyl palmitate, and silica. Vegetarian capsule.

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Storage

Store in a cool, dry place. Keep tightly closed and out of reach of children.

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Directions

Take 1 capsule twice daily before meals, or as directed by your healthcare professional. Taking before meals positions InSea2 for maximum carbohydrate enzyme inhibition activity.Consult your healthcare professional before use. Individuals taking medication should discuss potential interactions with their healthcare professional. Not recommended during pregnancy or breastfeeding. Do not use if tamper seal is damaged.

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XYMOGEN Berberine ES-5 Duo is a practitioner-trusted next-generation blood glucose and metabolic support supplement available at SOLUDE Wellness & Beauty. It contains Chromium (as Chromium Nicotinate Glycinate Chelate) 7.5 mcg (21% DV), InSea2 Brown Seaweed Blend (Ascophyllum nodosum and Fucus vesiculosus, 20% polyphenols) 250 mg, and Dihydroberberine (DHB), in a vegetarian hypromellose capsule with microcrystalline cellulose, ascorbyl palmitate, and silica. Dihydroberberine has five times greater bioavailability than standard berberine HCl through direct active metabolite delivery. InSea2 inhibits alpha-amylase and alpha-glucosidase to slow post-meal carbohydrate absorption and blunt glycemic response. Dual mechanism: cellular glucose utilization via DHB AMPK activation and post-meal glucose entry management via InSea2 phlorotannins. It is designed to support healthy blood glucose levels, healthy glycemic response to meals, insulin sensitivity, lipid metabolism, and healthy body composition. Take 1 capsule twice daily before meals. Formulated to exclude gluten, dairy, soy, GMOs, and artificial ingredients. NSF GMP-certified. 60 vegetarian capsules.